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chronic treatment rescued cognitive deficits, auditory hypersensitivity, aberrant dendritic spine density, overactive extracellular signal regulated kinase (ERK) and mammalian target of rapamycin (mTOR) signaling, and partially corrected macroorchidism in adult fragile X mice (Michalon et al., 2012)

5 Intervention strategies targeting ferroptosis in OA and future perspectives Having delineated the pathophysiological links between OA and ferroptosis, we now examine current and emerging therapeutic approaches that aim to block or mitigate ferroptosis and potentially preserve joint integrity

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